Alzain 200 mg Capsules, Hard

Alzain two hundred mg Capsules, Hard

2. Qualitative and quantitative composition
Each capsule, arduous contains two hundred mg of pregabalin.

For the total list of excipients, see section half dozen.1.

3. Pharmaceutical type
Capsule, hard.

The two hundred mg capsule is lightweight orange, size 1 (19.3 ± 0.4 mm), marked “PGB 200” on the body with black ink.

4. Clinical particulars
4.1 Therapeutic indications
Neuropathic pain

Alzain is indicated for the treatment of peripheral and central neuropathic pain in adults.

Epilepsy

Alzain is indicated as connected medical aid in adults with partial seizures with or while not secondary generalisation.

Generalised psychological disorder

Alzain is indicated for the treatment of Generalised psychological disorder (GAD) in adults.

4.2 materia medica and methodology of administration
Posology

The dose vary is one hundred fifty to 600 mg per day given in either 2 or 3 divided doses.

Neuropathic pain

Pregabalin treatment is started at a dose of one hundred fifty mg per day given as 2 or 3 divided doses. supported individual patient response and tolerability, the dose could also be inflated to three hundred mg per day once AN interval of three to seven days, and if required, to a most dose of 600 mg per day once a further 7-day interval.

Epilepsy

Pregabalin treatment is started with a dose of one hundred fifty mg per day given as 2 or 3 divided doses. supported individual patient response and tolerability, the dose could also be inflated to three hundred mg per day once one week. the utmost dose of 600 mg per day could also be achieved once a further week.

Generalised psychological disorder

The dose vary is one hundred fifty to 600 mg per day given as 2 or 3 divided doses. the requirement for treatment ought to be reassessed frequently.

Pregabalin treatment is started with a dose of one hundred fifty mg per day. supported individual patient response and tolerability, the dose could also be inflated to three hundred mg per day once one week. Following a further week the dose could also be inflated to 450 mg per day. the utmost dose of 600 mg per day could also be achieved once a further week.

Discontinuation of pregabalin

In accordance with current clinical apply, if pregabalin must be out of print it's counseled this could be done step by step over a minimum of one week freelance of the indication (see sections four.4 and 4.8).

Patients with urinary organ impairment

Pregabalin is eliminated from the circulation primarily by urinary organ excretion as unchanged drug. As pregabalin clearance is directly proportional to creatinine clearance (see section five.2), dose reduction in patients with compromised urinary organ operate should be personalized per creatinine clearance (CLcr), as indicated in Table one determined victimization the subsequent formula:



Pregabalin is removed effectively from plasma by hemodialysis (50 you look after drug in four hours). For patients receiving hemodialysis, the pregabalin daily dose ought to be adjusted supported urinary organ operate. additionally to the daily dose, a supplementary dose ought to run forthwith following each four hour hemodialysis treatment (see Table 1).

Table 1. Pregabalin dose adjustment supported urinary organ operate